Interdisciplinary investigations of the human osteological remains help us to understand the genetic diversity, the mobility or the paleodiet of the past communities and offer us insights on the diagenetic processes. The present study aims to assess the results of chemical, mineralogical and microscopic analyses performed on different human osteological remains selected from archaeological sites situated in Eastern Romania in order to understand the diagenetic transformations involved in the site formation processes and to estimate their influence on the historical interpretation.