In this article, we offer some philosophical notes on the so-called Plotinus sarcophagus, currently exhibited in the ‘Vatican Museums’ (inv. 9504), which has been dated to the end of the third quarter of the 3rd century. Since the sarcophagus in question has been the subject of discussion among experts since the 1920s, our aim is to contribute to the scientific debate with a number of philosophical remarks to assist in the interpretation of the iconographic representation of the teacher teaching, accompanied by two Muses, but also to make particular reference to certain passages taken from the On the Life of Plotinus, written by his disciple, Porphyry, three decades after the death of his teacher.